Karen Walker/Megan Mullally
I don't think I've come across a single person who watches Will and Grace and doesn't adore Karen. Sure she's a loud, pill popping, drunk but she's utterly fabulous. There's something about the way she can deliver a perfectly timed sarcastic comment while sipping a Martini, that just makes her irresistible. You'd expect that her insanely high pitched voice would be annoying but somehow it merely adds to her unique charm. She spends her days pretending to work and critiquing everything about Grace but you can tell that there's a deep friendship there, she has a similar relationship with her maid Rosario and even Will, she insults them but you know she loves them really. But her real devoted is of course to Jack; her poodle. Those two are inseparable and magnificent together, in fact they virtually steal the show. As the show progressed we can to see more of her personality as well as her general liking of French kissing girl, which lets face is what we had all been hoping for. Karen is one of a kind and I personally wouldn't change a thing about her.